Elizabeth Jamieson’s lab examines how complexes of the transition metal chromium damage DNA. She and her students use differential scanning calorimetry to see how lesions formed by chromium alter the thermodynamic stability of the DNA helix. They are also interested in investigating the structure of some of these lesions using NMR spectroscopy and seeing how they affect the structure of nucleosomes.

Selected Publications

Norabuena, E.M., Williams, S.B., Klureza, M.A., Goehring, L.J., Gruessner, B., Radhakrishnan, M.L., Jamieson, E.R. and Núñez, M.E., “Effect of the Spiroiminodihydantoin Lesion on Nucleosome Stability and Positioning” Biochemistry 2016, 55, 2411-2421. 

Gruessner, B., Dwarakanath, M., Stewart, E., Bae, Y., and Jamieson, E.R., “Effect of Base-Pairing Partner on the Thermodynamic Stability of the Diastereomeric Spiroiminodihydantoin Lesion,” Chem. Res. Toxicol. 2016, 29, 279-284. 

Jamieson, E.R., Eppley, H.J., Geselbracht, M.J., Johnson, A.R., Reisner, B.A., Smith, S.R., Stewart, J.L., Watson, L.A., Williams, B.S., "Inorganic Chemistry and IONiC: An Online Community Bringing Cutting-Edge Research into the Classroom," Inorganic Chemistry, 2011, 50, 5849-5854.

Stansfield, H.E., Kulczewski, B.P., Lybrand, K.E., Jamieson, E.R., "Identifying Protein Interactions with Metal-Modified DNA Using Microarray Technology," Journal of Biological Inorganic Chemistry, 2009, 14, 193-199.

Chinyengetere, F., Jamieson, E.R., "Impact of the Oxidized Guanine Lesion Spiroiminodihydantoin on the Conformation and Thermodynamic Stability of a 15-mer DNA Duplex," Biochemistry, 2008, 47, 2584-2591.

Chowdhury, T., Jamieson, E.R., "C4' Sugar Oxidation of Deoxyribonucleotide Triphosphates by Chromium(V) Complexes," Mutation Research, 2006, 610, 66-73.

Chen, B., Jamieson, E.R., Tullius, T.D., "A General Synthesis of Specifically Deuterated Nucleotides for Studies of DNA and RNA," Bioorganic & Medicinal Chemistry Letters, 2002, 12, 3093-3096.

Jamieson, E.R., Lippard, S.J., "Stopped-Flow Fluorescence Studies of HMG-Domain Protein Binding to Cisplatin-Modified DNA," Biochemistry, 2000, 39, 8426-8438.

Jamieson, E.R., Lippard, S.J., "Structure, Recognition, and Processing of Cisplatin-DNA Adducts," Chemical Reviews, 1999, 99, 2467-2498.