John Slepian’s artwork has been shown nationally and internationally at venues including P.S.1/MoMA and Hunter College art galleries in New York; the Exploratorium in San Francisco; Axiom Gallery, Boston Cyberarts Gallery, and the Boston Center for the Arts in Boston; the Re-New Digital Art Festival in Copenhagen, Denmark; and the 21st International Symposium on Electronic Art in Vancouver, Canada.

He was a resident in the P.S.1 National Studio Program in 2002–03, and in 2005–06 was awarded a New York Foundation for the Arts grant in computer arts. In 2014, he was co-awarded a Connecticut State Artist Fellowship for his work with Adele Myers and Dancers.

Slepian graduated from New York University with a bachelor’s in film and television and the San Francisco Art Institute with a master’s in new genres. For the 2019-20 school year, he served as the dean of visual arts at New World School of the Arts in Miami, Florida. Since 2007, Slepian has been an associate professor of art and technology at Hampshire and Smith colleges in western Massachusetts. He lives and works in the Greater Boston area.